DOI: 10.1073/pnas.80.12.3696. Dynamics of a small globular protein in terms of low-frequency vibrational modes.

Dynamics of a small globular protein in terms of low-frequency vibrational modes.

10.1073/pnas.80.12.3696

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Normal modes of low-frequency vibrations are calculated for a small globular protein, bovine pancreatic trypsin inhibitor. In modes with frequencies below 120 cm-1 the protein molecule behaves like a continuous elastic body. Most modes with frequencies above 50 cm-1 are shown to behave harmonically within the range of thermal fluctuations at room temperature. Those with frequencies below 50 cm-1 show some anharmonicity. Magnitudes of displacements of atoms are mainly determined by the modes with frequencies below 30 cm-1. These very-low-frequency modes contribute significantly to the entropy of the system. The dynamic structure of the globular protein is described as a superposition of harmonic high-frequency motions and coupled anharmonic low-frequency motions of collective variables corresponding to the normal modes of vibration.

Bibliography

Go, N., Noguti, T., & Nishikawa, T. (1983). Dynamics of a small globular protein in terms of low-frequency vibrational modes. Proceedings of the National Academy of Sciences, 80(12), 3696â3700.

Authors 3

N Go (first)
T Noguti (additional)
T Nishikawa (additional)

References 0 Referenced 618

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 5:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:52 a.m.)
Indexed	2 weeks, 2 days ago (Aug. 6, 2025, 8:53 a.m.)
Issued	42 years, 2 months ago (June 1, 1983)
Published	42 years, 2 months ago (June 1, 1983)
Published Online	42 years, 2 months ago (June 1, 1983)
Published Print	42 years, 2 months ago (June 1, 1983)

Funders 0

None

BibTeX

@article{Go_1983, title={Dynamics of a small globular protein in terms of low-frequency vibrational modes.}, volume={80}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.80.12.3696}, DOI={10.1073/pnas.80.12.3696}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Go, N and Noguti, T and Nishikawa, T}, year={1983}, month=jun, pages={3696–3700} }

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