DOI: 10.1073/pnas.79.4.973. Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

10.1073/pnas.79.4.973

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have identified the single phosphorylated tyrosine in p60src, the transforming protein of Rous sarcoma virus, as part of the sequence. NH2-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(P)-Thr-Ala-Arg-COOH. Therefore, this is a sequence that is recognized efficiently by a tyrosine protein kinase in vivo. Phosphorylation of tyrosine in cellular proteins appears to play a role in malignant transformation by four classes of genetically distinct RNA tumor viruses. Phosphorylated tyrosines in several other proteins resemble of the tyrosine in p60src in that they are located 7 residues to the COOH-terminal side of a basic amino acid and either 4 residues to the COOH-terminal side of, or in close proximity to, a glutamic acid residue. Therefore it is possible that these features play a role in the selection of sites of phosphorylation by some tyrosine protein kinases. However, several clear exceptions to this rule exist.

Bibliography

Patschinsky, T., Hunter, T., Esch, F. S., Cooper, J. A., & Sefton, B. M. (1982). Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proceedings of the National Academy of Sciences, 79(4), 973â977.

Authors 5

T Patschinsky (first)
T Hunter (additional)
F S Esch (additional)
J A Cooper (additional)
B M Sefton (additional)

References 0 Referenced 210

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 5 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:48 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:21 a.m.)
Issued	43 years, 6 months ago (Feb. 1, 1982)
Published	43 years, 6 months ago (Feb. 1, 1982)
Published Online	43 years, 6 months ago (Feb. 1, 1982)
Published Print	43 years, 6 months ago (Feb. 1, 1982)

Funders 0

None

BibTeX

@article{Patschinsky_1982, title={Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.}, volume={79}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.79.4.973}, DOI={10.1073/pnas.79.4.973}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Patschinsky, T and Hunter, T and Esch, F S and Cooper, J A and Sefton, B M}, year={1982}, month=feb, pages={973–977} }

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