DOI: 10.1073/pnas.79.24.7689. Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.

Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.

10.1073/pnas.79.24.7689

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Sequences required for the regulated expression of a yeast histone 2A (H2A) gene have been investigated by using fusions between this gene and the Escherichia coli lacZ gene. Fusions containing the entire spacer region in which divergent transcription of the H2A and H2B genes is initiated result in low-level constitutive synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in yeast. Regulated expression (which is characterized by periodic synthesis during the S phase of the cell cycle) is restored when a 1.3-kilobase HindIII fragment containing a small region of the 3' end of the H2B gene is present in either orientation. The regulatory activity in this region appears to be coincident with a sequence that supports autonomous replication in yeast.

Bibliography

Osley, M. A., & Hereford, L. (1982). Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA. Proceedings of the National Academy of Sciences, 79(24), 7689â7693.

Authors 2

M A Osley (first)
L Hereford (additional)

References 0 Referenced 46

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 5 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:02 p.m.)
Indexed	4 months, 2 weeks ago (April 4, 2025, 1:43 a.m.)
Issued	42 years, 8 months ago (Dec. 1, 1982)
Published	42 years, 8 months ago (Dec. 1, 1982)
Published Online	42 years, 8 months ago (Dec. 1, 1982)
Published Print	42 years, 8 months ago (Dec. 1, 1982)

Funders 0

None

BibTeX

@article{Osley_1982, title={Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.}, volume={79}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.79.24.7689}, DOI={10.1073/pnas.79.24.7689}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Osley, M A and Hereford, L}, year={1982}, month=dec, pages={7689–7693} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        4
      ]
    ],
    "date-time": "2025-04-04T05:43:53Z",
    "timestamp": 1743745433329
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "24",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "abstract": "<jats:p>Sequences required for the regulated expression of a yeast histone 2A (H2A) gene have been investigated by using fusions between this gene and the Escherichia coli lacZ gene. Fusions containing the entire spacer region in which divergent transcription of the H2A and H2B genes is initiated result in low-level constitutive synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in yeast. Regulated expression (which is characterized by periodic synthesis during the S phase of the cell cycle) is restored when a 1.3-kilobase HindIII fragment containing a small region of the 3' end of the H2B gene is present in either orientation. The regulatory activity in this region appears to be coincident with a sequence that supports autonomous replication in yeast.</jats:p>",
  "DOI": "10.1073/pnas.79.24.7689",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        5,
        31
      ]
    ],
    "date-time": "2006-05-31T09:00:38Z",
    "timestamp": 1149066038000
  },
  "page": "7689-7693",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 46,
  "title": "Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.",
  "prefix": "10.1073",
  "volume": "79",
  "author": [
    {
      "given": "M A",
      "family": "Osley",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "L",
      "family": "Hereford",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.79.24.7689",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T16:02:48Z",
    "timestamp": 1649865768000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.79.24.7689"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "24",
    "published-print": {
      "date-parts": [
        [
          1982,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.79.24.7689"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.79.24.7689",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "assertion": [
    {
      "value": "1982-12-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}