DOI: 10.1073/pnas.79.21.6603. Genetic analysis of life-span in Caenorhabditis elegans.

Genetic analysis of life-span in Caenorhabditis elegans.

10.1073/pnas.79.21.6603

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Crosses between Bristol and Bergerac strains of the self-fertilizing hermaphroditic nematode Caenorhabditis elegans do not show the heterosis effects for life-span that complicate analysis of interstrain crosses with Drosophila or mice. Instead they yield F1 progeny with life-spans similar to those of the parent strains. By analysis of life-span variation among progeny F2 populations from such crosses and by two independent analyses of life-spans among recombinant inbred lines derived from F2 individuals by 18 rounds of self-fertilization, we estimate that the heritability of life-span in C. elegans is between 20% and 50%. Recombinant inbred lines show a range in mean life-spans of 10 days to 31 days compared to life-spans of about 18 days for each of the two parental strains. We conclude that life-span variation in C. elegans has a substantial genetic component and that this organism offers promising opportunities for selective breeding of longer-lived strains and genetic analysis of senescence.

Bibliography

Johnson, T. E., & Wood, W. B. (1982). Genetic analysis of life-span in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, 79(21), 6603â6607.

Authors 2

T E Johnson (first)
W B Wood (additional)

References 0 Referenced 207

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 4:58 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:58 a.m.)
Indexed	1 week, 4 days ago (Aug. 20, 2025, 9:23 a.m.)
Issued	42 years, 9 months ago (Nov. 1, 1982)
Published	42 years, 9 months ago (Nov. 1, 1982)
Published Online	42 years, 9 months ago (Nov. 1, 1982)
Published Print	42 years, 9 months ago (Nov. 1, 1982)

Funders 0

None

BibTeX

@article{Johnson_1982, title={Genetic analysis of life-span in Caenorhabditis elegans.}, volume={79}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.79.21.6603}, DOI={10.1073/pnas.79.21.6603}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Johnson, T E and Wood, W B}, year={1982}, month=nov, pages={6603–6607} }

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