DOI: 10.1073/pnas.79.2.253. Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae.

Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae.

10.1073/pnas.79.2.253

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In the present study we have analyzed the kinetics of DNase I digestion of the two alcohol dehydrogenase (ADH) genes within yeast nuclei. We have found that in yeast grown on glucose the constitutively transcribed ADCI gene is much more sensitive to DNase I digestion than is the repressible ADR2 gene. In yeast grown on ethanol, both genes are transcribed and both exhibit the same sensitivity to DNase I attack. We have also found and mapped DNase I hypersensitive sites near the 5' ends of constitutive and repressible ADH genes. These sites are well correlated with the position at which transcription is initiated.

Bibliography

Sledziewski, A., & Young, E. T. (1982). Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences, 79(2), 253â256.

Authors 2

A Sledziewski (first)
E T Young (additional)

References 0 Referenced 26

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 4:55 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:34 a.m.)
Indexed	1 year, 10 months ago (Oct. 25, 2023, 1:15 a.m.)
Issued	43 years, 8 months ago (Jan. 1, 1982)
Published	43 years, 8 months ago (Jan. 1, 1982)
Published Online	43 years, 8 months ago (Jan. 1, 1982)
Published Print	43 years, 8 months ago (Jan. 1, 1982)

Funders 0

None

BibTeX

@article{Sledziewski_1982, title={Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae.}, volume={79}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.79.2.253}, DOI={10.1073/pnas.79.2.253}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sledziewski, A and Young, E T}, year={1982}, month=jan, pages={253–256} }

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