DOI: 10.1073/pnas.79.15.4714. Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes.

Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes.

10.1073/pnas.79.15.4714

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Retroviral transforming genes, v-onc genes, are derived from normal cellular sequences that are called cellular onc (c-onc) genes. DNA from mouse-human somatic cell hybrids that have selectively lost human chromosomes was used in Southern blots to map the chromosomal location of two human onc genes. Cloned human homologues of retroviral onc genes were used as probes. Because the human c-fes gene, which is homologous to feline sarcoma virus, segregates concordantly with human chromosome 15, and the human c-myb gene, which is homologous to avian myeloblastosis virus onc genes, segregates concordantly with human chromosome 6, we have assigned the c-fes and the c-myb genes to human chromosomes 15 and 6, respectively. Nonrandom chromosomal defects involving these human chromosomes have been observed in neoplasms. These studies should be valuable in determining whether specific rearrangements involving these chromosomes result in the abnormal expression of these onc genes in human malignancies.

Bibliography

Dalla-Favera, R., Franchini, G., Martinotti, S., Wong-Staal, F., Gallo, R. C., & Croce, C. M. (1982). Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proceedings of the National Academy of Sciences, 79(15), 4714â4717.

Authors 6

R Dalla-Favera (first)
G Franchini (additional)
S Martinotti (additional)
F Wong-Staal (additional)
R C Gallo (additional)
C M Croce (additional)

References 0 Referenced 44

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 4:51 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:25 a.m.)
Indexed	4 months, 1 week ago (April 19, 2025, 4:48 a.m.)
Issued	43 years ago (Aug. 1, 1982)
Published	43 years ago (Aug. 1, 1982)
Published Online	43 years ago (Aug. 1, 1982)
Published Print	43 years ago (Aug. 1, 1982)

Funders 0

None

BibTeX

@article{Dalla_Favera_1982, title={Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes.}, volume={79}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.79.15.4714}, DOI={10.1073/pnas.79.15.4714}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Dalla-Favera, R and Franchini, G and Martinotti, S and Wong-Staal, F and Gallo, R C and Croce, C M}, year={1982}, month=aug, pages={4714–4717} }

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