DOI: 10.1073/pnas.78.7.4156. Complete amino acid sequence of beta-tubulin from porcine brain.

Complete amino acid sequence of beta-tubulin from porcine brain.

10.1073/pnas.78.7.4156

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The primary structure of porcine brain beta-tubulin was determined by automated and manual Edman degradation of six sets of overlapping peptides. The protein consists of 445 amino acid residues and has a minimum of six positions that are heterogeneous, indicating at least two beta-tubulins in porcine brain. Comparison of the optimally aligned sequences of alpha-tubulin and beta-tubulin indicates that 41% of their primary structures are identical. A region rich in glycyl residues is similar both in sequence and predicted secondary structure to the phosphate binding loop of several nucleotide binding enzymes. beta-Tubulin contains a highly acidic COOH-terminal region that resembles the NH2-terminus of troponin T.

Bibliography

Krauhs, E., Little, M., Kempf, T., Hofer-Warbinek, R., Ade, W., & Ponstingl, H. (1981). Complete amino acid sequence of beta-tubulin from porcine brain. Proceedings of the National Academy of Sciences, 78(7), 4156â4160.

Authors 6

E Krauhs (first)
M Little (additional)
T Kempf (additional)
R Hofer-Warbinek (additional)
W Ade (additional)
H Ponstingl (additional)

References 0 Referenced 192

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 4:44 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:38 a.m.)
Indexed	3 weeks, 4 days ago (Aug. 2, 2025, 1:26 a.m.)
Issued	44 years, 1 month ago (July 1, 1981)
Published	44 years, 1 month ago (July 1, 1981)
Published Online	44 years, 1 month ago (July 1, 1981)
Published Print	44 years, 1 month ago (July 1, 1981)

Funders 0

None

BibTeX

@article{Krauhs_1981, title={Complete amino acid sequence of beta-tubulin from porcine brain.}, volume={78}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.78.7.4156}, DOI={10.1073/pnas.78.7.4156}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Krauhs, E and Little, M and Kempf, T and Hofer-Warbinek, R and Ade, W and Ponstingl, H}, year={1981}, month=jul, pages={4156–4160} }

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