DOI: 10.1073/pnas.78.11.6840. An amplified sensitivity arising from covalent modification in biological systems.

An amplified sensitivity arising from covalent modification in biological systems.

10.1073/pnas.78.11.6840

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric proteins with high Hill coefficients.

Bibliography

Goldbeter, A., & Koshland, D. E. (1981). An amplified sensitivity arising from covalent modification in biological systems. Proceedings of the National Academy of Sciences, 78(11), 6840â6844.

Authors 2

A Goldbeter (first)
D E Koshland (additional)

References 0 Referenced 1,023

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 4:36 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:26 a.m.)
Indexed	3 days, 8 hours ago (Aug. 26, 2025, 2:44 a.m.)
Issued	43 years, 9 months ago (Nov. 1, 1981)
Published	43 years, 9 months ago (Nov. 1, 1981)
Published Online	43 years, 9 months ago (Nov. 1, 1981)
Published Print	43 years, 9 months ago (Nov. 1, 1981)

Funders 0

None

BibTeX

@article{Goldbeter_1981, title={An amplified sensitivity arising from covalent modification in biological systems.}, volume={78}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.78.11.6840}, DOI={10.1073/pnas.78.11.6840}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Goldbeter, A and Koshland, D E}, year={1981}, month=nov, pages={6840–6844} }

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