DOI: 10.1073/pnas.77.3.1651. Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion

Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion

10.1073/pnas.77.3.1651

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

By a combination of the indirect immunofluorescence technique with acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) staining, it was shown that vasoactive intestinal polypeptide (VIP) is present in cholinergic (acetylcholinesterase-rich) neurons involved in control of secretion and vasodilation in exocrine glands of cat. The submandibular salivary gland was used as a functional model. Preganglionic nerve stimulation induced an atropine-resistant, hexamethonium-sensitive vasodilation and release of VIP into the venous outflow from the gland and an atropine- and hexamethonium-sensitive secretion. Infusion of VIP antiserum reduced both the vasodilation and secretion. Infusion of VIP caused vasodilation only, whereas acetylcholine caused both vasodilation and secretion. Simultaneous infusion of VIP and acetylcholine in low doses resulted in a marked potentiation of both vasodilation and secretion. The present morphological and functional data support the following hypothesis for regulation of vasodilation and secretion in exocrine glands. Preganglionic cholinergic nerves activate, via nicotinic receptors, postganglionic neurons, causing concomitant release from the same nerve endings of two coexisting putative transmitters, acetylcholine and VIP. Acetylcholine produces mainly secretion by a muscarinic action and VIP causes mainly vasodilation, but the two substances seem to cooperate directly or indirectly in both types of response. Thus, the coexistence of two putative neurotransmitters, VIP and acetylcholine, in one neuron may explain the dual effector response (i.e., the cholinergic secretion and the atropine-resistant vasodilation) caused by nerve stimulation in exocrine glands.

Bibliography

Lundberg, J. M., ÃnggÃ¤rd, A., Fahrenkrug, J., HÃ¶kfelt, T., & Mutt, V. (1980). Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion. Proceedings of the National Academy of Sciences, 77(3), 1651â1655.

Authors 5

Jan M. Lundberg (first)
Anders Änggärd (additional)
Jan Fahrenkrug (additional)
Tomas Hökfelt (additional)
Viktor Mutt (additional)

References 0 Referenced 272

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 4:11 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:18 a.m.)
Indexed	1 week, 6 days ago (Aug. 19, 2025, 6:10 a.m.)
Issued	45 years, 6 months ago (March 1, 1980)
Published	45 years, 6 months ago (March 1, 1980)
Published Online	45 years, 6 months ago (March 1, 1980)
Published Print	45 years, 6 months ago (March 1, 1980)

Funders 0

None

BibTeX

@article{Lundberg_1980, title={Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion}, volume={77}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.77.3.1651}, DOI={10.1073/pnas.77.3.1651}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lundberg, Jan M. and Änggärd, Anders and Fahrenkrug, Jan and Hökfelt, Tomas and Mutt, Viktor}, year={1980}, month=mar, pages={1651–1655} }

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