Abstract
A single-point mutation, consisting of a T-to-G transversion, was made in the third nucleotide of the conalbumin gene T-A-T-A-A-A-A homology sequence (the T-A-T-A or Goldberg-Hogness box). In an in vitro system, specific transcription of the mutant DNA was drastically decreased compared to the normal gene. This down-mutation is consistent with the idea that the T-A-T-A box is an important element for specific initiation of transcription.
Bibliography
Wasylyk, B., Derbyshire, R., Guy, A., Molko, D., Roget, A., Téoule, R., & Chambon, P. (1980). Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proceedings of the National Academy of Sciences, 77(12), 7024â7028.
Dates
| Type | When |
|---|---|
| Created | 19 years, 3 months ago (May 31, 2006, 4:08 a.m.) |
| Deposited | 3 years, 4 months ago (April 13, 2022, 11:18 a.m.) |
| Indexed | 1 year ago (Aug. 5, 2024, 3:54 p.m.) |
| Issued | 44 years, 8 months ago (Dec. 1, 1980) |
| Published | 44 years, 8 months ago (Dec. 1, 1980) |
| Published Online | 44 years, 8 months ago (Dec. 1, 1980) |
| Published Print | 44 years, 8 months ago (Dec. 1, 1980) |
@article{Wasylyk_1980, title={Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence.}, volume={77}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.77.12.7024}, DOI={10.1073/pnas.77.12.7024}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Wasylyk, B and Derbyshire, R and Guy, A and Molko, D and Roget, A and Téoule, R and Chambon, P}, year={1980}, month=dec, pages={7024–7028} }