Abstract
The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.
Dates
Type | When |
---|---|
Created | 19 years, 2 months ago (May 31, 2006, 4:08 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 11:40 a.m.) |
Indexed | 1 month, 3 weeks ago (July 6, 2025, 1:26 p.m.) |
Issued | 44 years, 9 months ago (Nov. 1, 1980) |
Published | 44 years, 9 months ago (Nov. 1, 1980) |
Published Online | 44 years, 9 months ago (Nov. 1, 1980) |
Published Print | 44 years, 9 months ago (Nov. 1, 1980) |
@article{Hjelmeland_1980, title={A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.}, volume={77}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.77.11.6368}, DOI={10.1073/pnas.77.11.6368}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hjelmeland, L M}, year={1980}, month=nov, pages={6368–6370} }