DOI: 10.1073/pnas.77.10.6124. delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.

delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.

10.1073/pnas.77.10.6124

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The hepatitis B virus-associated beta antigen was found in the serum of experimentally infected chimpanzee as an internal component of a discrete subpopulation of hepatitis B surface antigen (HBsAg) particles. The 35- to 37-nm particles banded in CsCl at 1.24-1.25 g/cm3 and sedimented with a mobility intermediate between that of the hepatitis B virion and that of the 22-nm form of HBsAg. The particles contained only indistinct internal structure by electron microscopy and were not unique to delta agent infection, similar particles without delta-antigen activity being observed in the preinfection serum of HBsAg carrier chimpanzees. A small RNA (Mr, 5 X 10(5)) was temporally associated with delta antigen in the serum of infected chimpanzees and copurified with the delta-antigen-associated particles. This RNA is smaller than the genomes of known RNA viruses but larger than the viroids of higher plants.

Bibliography

Rizzetto, M., Hoyer, B., Canese, M. G., Shih, J. W., Purcell, R. H., & Gerin, J. L. (1980). delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees. Proceedings of the National Academy of Sciences, 77(10), 6124â6128.

Authors 6

M Rizzetto (first)
B Hoyer (additional)
M G Canese (additional)
J W Shih (additional)
R H Purcell (additional)
J L Gerin (additional)

References 0 Referenced 340

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 4:06 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:27 a.m.)
Indexed	2 days, 21 hours ago (Sept. 4, 2025, 9:53 a.m.)
Issued	44 years, 11 months ago (Oct. 1, 1980)
Published	44 years, 11 months ago (Oct. 1, 1980)
Published Online	44 years, 11 months ago (Oct. 1, 1980)
Published Print	44 years, 11 months ago (Oct. 1, 1980)

Funders 0

None

BibTeX

@article{Rizzetto_1980, title={delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.}, volume={77}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.77.10.6124}, DOI={10.1073/pnas.77.10.6124}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Rizzetto, M and Hoyer, B and Canese, M G and Shih, J W and Purcell, R H and Gerin, J L}, year={1980}, month=oct, pages={6124–6128} }

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