DOI: 10.1073/pnas.76.6.2644. Fibronectin and the multiple interaction model for platelet-collagen adhesion.

Fibronectin and the multiple interaction model for platelet-collagen adhesion.

10.1073/pnas.76.6.2644

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A rapid, sensitive, and reproducible assay to determine the adhesion of platelets to collagen has been developed. Collagen fibers and adherent platelets are retained on polycarbonate membrane filters. Chemical modification of collagen by acetylation and of platelets by treatment with chymotrypsin markedly reduces adhesion. The role of fibronectin in the collagen-platelet interaction has been examined. Treatment of platelets with purified antibody or Fab' fragments to fibronectin only slightly reduces adhesion. Preincubation of platelets with high concentrations of gelatin reduces adhesion by only 22% but fails to inhibit aggregation. Thus, fibronectin has only a limited role in the adhesion of platelets to collagen and is either not involved in the adhesion that leads to aggregation or is only one of several adhesion mechanisms, any of which alone can initiate aggregation.

Bibliography

Santoro, S. A., & Cunningham, L. W. (1979). Fibronectin and the multiple interaction model for platelet-collagen adhesion. Proceedings of the National Academy of Sciences, 76(6), 2644â2648.

Authors 2

S A Santoro (first)
L W Cunningham (additional)

References 0 Referenced 49

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:59 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:22 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 4:02 p.m.)
Issued	46 years, 3 months ago (June 1, 1979)
Published	46 years, 3 months ago (June 1, 1979)
Published Online	46 years, 3 months ago (June 1, 1979)
Published Print	46 years, 3 months ago (June 1, 1979)

Funders 0

None

BibTeX

@article{Santoro_1979, title={Fibronectin and the multiple interaction model for platelet-collagen adhesion.}, volume={76}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.76.6.2644}, DOI={10.1073/pnas.76.6.2644}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Santoro, S A and Cunningham, L W}, year={1979}, month=jun, pages={2644–2648} }

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