DOI: 10.1073/pnas.76.2.935. Comparison of structure and function of human erythrocyte and human muscle actin.

Comparison of structure and function of human erythrocyte and human muscle actin.

10.1073/pnas.76.2.935

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Human erythrocyte actin and human skeletal muscle actin were purified by acetone powder extraction and gel filtration. Pure human erythrocyte actin resembles muscle actin in its polymerization and depolymerization by phalloidin, cytochalasin B, and DNase I, in its peptide mapping pattern, and in the amino acid composition of corresponding peptides. Isoelectric focusing gel analysis showed that human erythrocyte actin exists in the beta/gamma form, but muscle actin is in the alpha form. Abnormal deformability of resealed erythrocyte membranes was observed after incorporation of the actin-specific agents, phalloidin and DNase I, suggesting that erythrocyte actin might function as a membrane structural element to maintain erythrocyte membrane deformability.

Bibliography

Nakashima, K., & Beutler, E. (1979). Comparison of structure and function of human erythrocyte and human muscle actin. Proceedings of the National Academy of Sciences, 76(2), 935â938.

Authors 2

K Nakashima (first)
E Beutler (additional)

References 0 Referenced 14

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:53 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:56 a.m.)
Indexed	1 year, 10 months ago (Oct. 23, 2023, 4:58 a.m.)
Issued	46 years, 6 months ago (Feb. 1, 1979)
Published	46 years, 6 months ago (Feb. 1, 1979)
Published Online	46 years, 6 months ago (Feb. 1, 1979)
Published Print	46 years, 6 months ago (Feb. 1, 1979)

Funders 0

None

BibTeX

@article{Nakashima_1979, title={Comparison of structure and function of human erythrocyte and human muscle actin.}, volume={76}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.76.2.935}, DOI={10.1073/pnas.76.2.935}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Nakashima, K and Beutler, E}, year={1979}, month=feb, pages={935–938} }

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