DOI: 10.1073/pnas.76.1.425. Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.

10.1073/pnas.76.1.425

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.

Bibliography

Chesebro, B., & Wehrly, K. (1979). Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proceedings of the National Academy of Sciences, 76(1), 425â429.

Authors 2

B Chesebro (first)
K Wehrly (additional)

References 0 Referenced 78

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:47 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:52 a.m.)
Indexed	4 months, 2 weeks ago (April 9, 2025, 12:45 a.m.)
Issued	46 years, 7 months ago (Jan. 1, 1979)
Published	46 years, 7 months ago (Jan. 1, 1979)
Published Online	46 years, 7 months ago (Jan. 1, 1979)
Published Print	46 years, 7 months ago (Jan. 1, 1979)

Funders 0

None

BibTeX

@article{Chesebro_1979, title={Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.}, volume={76}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.76.1.425}, DOI={10.1073/pnas.76.1.425}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chesebro, B and Wehrly, K}, year={1979}, month=jan, pages={425–429} }

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