DOI: 10.1073/pnas.75.12.5893. Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

10.1073/pnas.75.12.5893

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kinase and the endonuclease have been partially purified from interferon-treated Ehrlich ascites tumor cells. The 2',5'-oligoadenylates [pppA(2'p5'A)n], found found earlier to be mediators in the activation of the endonuclease by double-stranded RNA, are not mediators in the activation of the protein kinase by double-stranded RNA.

Bibliography

Farrell, P. J., Sen, G. C., Dubois, M. F., Ratner, L., Slattery, E., & Lengyel, P. (1978). Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA. Proceedings of the National Academy of Sciences, 75(12), 5893â5897.

Authors 6

P J Farrell (first)
G C Sen (additional)
M F Dubois (additional)
L Ratner (additional)
E Slattery (additional)
P Lengyel (additional)

References 0 Referenced 144

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:38 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:10 a.m.)
Indexed	5 months, 1 week ago (March 19, 2025, 11:40 a.m.)
Issued	46 years, 9 months ago (Dec. 1, 1978)
Published	46 years, 9 months ago (Dec. 1, 1978)
Published Online	46 years, 9 months ago (Dec. 1, 1978)
Published Print	46 years, 9 months ago (Dec. 1, 1978)

Funders 0

None

BibTeX

@article{Farrell_1978, title={Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.}, volume={75}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.75.12.5893}, DOI={10.1073/pnas.75.12.5893}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Farrell, P J and Sen, G C and Dubois, M F and Ratner, L and Slattery, E and Lengyel, P}, year={1978}, month=dec, pages={5893–5897} }

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