DOI: 10.1073/pnas.74.7.2855. Extensive disulfide bonding at the mammalian cell surface.

Extensive disulfide bonding at the mammalian cell surface.

10.1073/pnas.74.7.2855

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cell surface proteins of cultured cells are disulfide bonded to a greater degree than are total cellular proteins. In particular, the "large external transformation-sensitive" (LETS) protein, a major surface protein, is present almost exclusively in disulfide-bonded complexes including homodimers and also higher aggregates held together by disulfide bonds or concovalent interactions. Other cell surface proteins also appear to be involved in disulfide bonding, both intramolecular and intermolecular. In virally transformed cells, LETS protein and its disulfide complexes are absent and certain other disulfide-bonded proteins are also not observed.

Bibliography

Hynes, R. O., & Destree, A. (1977). Extensive disulfide bonding at the mammalian cell surface. Proceedings of the National Academy of Sciences, 74(7), 2855â2859.

Authors 2

R O Hynes (first)
A Destree (additional)

References 0 Referenced 104

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:33 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:17 a.m.)
Indexed	1 month, 4 weeks ago (July 1, 2025, 12:31 p.m.)
Issued	48 years, 1 month ago (July 1, 1977)
Published	48 years, 1 month ago (July 1, 1977)
Published Online	48 years, 1 month ago (July 1, 1977)
Published Print	48 years, 1 month ago (July 1, 1977)

Funders 0

None

BibTeX

@article{Hynes_1977, title={Extensive disulfide bonding at the mammalian cell surface.}, volume={74}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.74.7.2855}, DOI={10.1073/pnas.74.7.2855}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hynes, R O and Destree, A}, year={1977}, month=jul, pages={2855–2859} }

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