DOI: 10.1073/pnas.74.2.689. Effects of ribosomal mutations on the read-through of a chain termination signal: studies on the synthesis of bacteriophage lambda O gene protein in vitro.

Effects of ribosomal mutations on the read-through of a chain termination signal: studies on the synthesis of bacteriophage lambda O gene protein in vitro.

10.1073/pnas.74.2.689

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In a DNA-dependent protein-synthesizing system that contains streptomycin-sensitive ribosomes, lambda DNA directs the synthesis of two proteins that are products of the O gene. The larger is produced as a result of read-through of a UGA termination codon. In the system containing streptomycin-resistant ribosomes this read-through protein is not synthesized, indicating that the mutational alteration in the ribosomal protein S12 restricts the read-through. The mutant ribosomes also fail to synthesize the read-through coat protein of RNA phage Qbeta. In addition, the mutant ribosomes restrict suppression of amber mutations in vitro, similar to their effect in vivo.

Bibliography

Yates, J. L., Gette, W. R., Furth, M. E., & Nomura, M. (1977). Effects of ribosomal mutations on the read-through of a chain termination signal: studies on the synthesis of bacteriophage lambda O gene protein in vitro. Proceedings of the National Academy of Sciences, 74(2), 689â693.

Authors 4

J L Yates (first)
W R Gette (additional)
M E Furth (additional)
M Nomura (additional)

References 0 Referenced 50

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:25 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:12 a.m.)
Indexed	1 year, 2 months ago (May 31, 2024, 7:59 a.m.)
Issued	48 years, 6 months ago (Feb. 1, 1977)
Published	48 years, 6 months ago (Feb. 1, 1977)
Published Online	48 years, 6 months ago (Feb. 1, 1977)
Published Print	48 years, 6 months ago (Feb. 1, 1977)

Funders 0

None

BibTeX

@article{Yates_1977, title={Effects of ribosomal mutations on the read-through of a chain termination signal: studies on the synthesis of bacteriophage lambda O gene protein in vitro.}, volume={74}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.74.2.689}, DOI={10.1073/pnas.74.2.689}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Yates, J L and Gette, W R and Furth, M E and Nomura, M}, year={1977}, month=feb, pages={689–693} }

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