DOI: 10.1073/pnas.74.12.5618. Molecular evolution of human and rabbit beta-globin mRNAs.

Molecular evolution of human and rabbit beta-globin mRNAs.

10.1073/pnas.74.12.5618

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The primary structures of human and rabbit beta-globin mRNAs are compared. Using as a standard the extent of nucleotide substitutions inferred from the hypervariable amino acid residues of fibrinopeptides A and B, which are thought to change largely by neutral evolution, we show that not all silent mutations in globin mRNA are neutral. The divergence of the sequences is limited in part by the selective usage of synonymous codons. The divergent nucleotides tend to be distributed nonrandomly: in the coding region silent substitutions are most rare in segments that are also deficient in substitutions leading to replacements.

Bibliography

Kafatos, F. C., Efstratiadis, A., Forget, B. G., & Weissman, S. M. (1977). Molecular evolution of human and rabbit beta-globin mRNAs. Proceedings of the National Academy of Sciences, 74(12), 5618â5622.

Authors 4

F C Kafatos (first)
A Efstratiadis (additional)
B G Forget (additional)
S M Weissman (additional)

References 0 Referenced 72

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:25 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:16 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 7:29 a.m.)
Issued	47 years, 9 months ago (Dec. 1, 1977)
Published	47 years, 9 months ago (Dec. 1, 1977)
Published Online	47 years, 9 months ago (Dec. 1, 1977)
Published Print	47 years, 9 months ago (Dec. 1, 1977)

Funders 0

None

BibTeX

@article{Kafatos_1977, title={Molecular evolution of human and rabbit beta-globin mRNAs.}, volume={74}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.74.12.5618}, DOI={10.1073/pnas.74.12.5618}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kafatos, F C and Efstratiadis, A and Forget, B G and Weissman, S M}, year={1977}, month=dec, pages={5618–5622} }

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