DOI: 10.1073/pnas.73.5.1679. Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.

Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.

10.1073/pnas.73.5.1679

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Unlabeled cholera toxin inhibits [125I]thyrotropin binding to thyrotropin receptors on thyroid plasma membranes. Maximal inhibition by cholera toxin does not exceed 40%, whereas unalbeled thyrotropin completely inhibits [125I]thyrotropin binding to these same membranes. Kinetic analyses of the binding data are compatible with the view that the cholera toxin decreases the number of receptor sites available to thyrotropin and that the mechanism by which the cholera toxin inhibits [125I]thyrotropin binding to these receptor sites involves both competitive and noncompetitive elements.

Bibliography

Mullin, B. R., Aloj, S. M., Fishman, P. H., Lee, G., Kohn, L. D., & Brady, R. O. (1976). Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes. Proceedings of the National Academy of Sciences, 73(5), 1679â1683.

Authors 6

B R Mullin (first)
S M Aloj (additional)
P H Fishman (additional)
G Lee (additional)
L D Kohn (additional)
R O Brady (additional)

References 0 Referenced 79

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:17 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:56 a.m.)
Indexed	5 months ago (April 4, 2025, 11:44 a.m.)
Issued	49 years, 4 months ago (May 1, 1976)
Published	49 years, 4 months ago (May 1, 1976)
Published Online	49 years, 4 months ago (May 1, 1976)
Published Print	49 years, 4 months ago (May 1, 1976)

Funders 0

None

BibTeX

@article{Mullin_1976, title={Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.}, volume={73}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.73.5.1679}, DOI={10.1073/pnas.73.5.1679}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mullin, B R and Aloj, S M and Fishman, P H and Lee, G and Kohn, L D and Brady, R O}, year={1976}, month=may, pages={1679–1683} }

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