DOI: 10.1073/pnas.73.5.1547. Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.

Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.

10.1073/pnas.73.5.1547

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have developed a method of r the direct measurement, in eukaryotic cells, of the synthesis of ribosomal proteins, irrespective of the synthesis of ribosomes. In this way the synthesis of ribosomal proteins has been examined in mutant strains of Saccharomyces cerevisiae, which are unable to synthesize ribosomes under nonpermissive conditions. The results suggest that the synthesis of more than 40 ribosomal proteins is under coordinate control. Under nonpermissive conditions,the synthesis of each h protein declines exponentially to a basal level which is 10-20% fo normal. The kinetics of that decline suggest that an early, if not primary, result of the nonpermissive conditions is the cessation of production of new mRNA for eac of the ribosomal proteins. The coordinate regulation appears not to be influenced directly by the rate of transcription of ribosomal precursor RNA.

Bibliography

Gorenstein, C., & Warner, J. R. (1976). Coordinate regulation of the synthesis of eukaryotic ribosomal proteins. Proceedings of the National Academy of Sciences, 73(5), 1547â1551.

Authors 2

C Gorenstein (first)
J R Warner (additional)

References 0 Referenced 131

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:17 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:56 a.m.)
Indexed	1 day, 15 hours ago (Aug. 29, 2025, 6:04 a.m.)
Issued	49 years, 3 months ago (May 1, 1976)
Published	49 years, 3 months ago (May 1, 1976)
Published Online	49 years, 3 months ago (May 1, 1976)
Published Print	49 years, 3 months ago (May 1, 1976)

Funders 0

None

BibTeX

@article{Gorenstein_1976, title={Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.}, volume={73}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.73.5.1547}, DOI={10.1073/pnas.73.5.1547}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Gorenstein, C and Warner, J R}, year={1976}, month=may, pages={1547–1551} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        29
      ]
    ],
    "date-time": "2025-08-29T10:04:15Z",
    "timestamp": 1756461855808
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "5",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1976,
        5
      ]
    ]
  },
  "abstract": "<jats:p>We have developed a method of r the direct measurement, in eukaryotic cells, of the synthesis of ribosomal proteins, irrespective of the synthesis of ribosomes. In this way the synthesis of ribosomal proteins has been examined in mutant strains of Saccharomyces cerevisiae, which are unable to synthesize ribosomes under nonpermissive conditions. The results suggest that the synthesis of more than 40 ribosomal proteins is under coordinate control. Under nonpermissive conditions,the synthesis of each h protein declines exponentially to a basal level which is 10-20% fo normal. The kinetics of that decline suggest that an early, if not primary, result of the nonpermissive conditions is the cessation of production of new mRNA for eac of the ribosomal proteins. The coordinate regulation appears not to be influenced directly by the rate of transcription of ribosomal precursor RNA.</jats:p>",
  "DOI": "10.1073/pnas.73.5.1547",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        5,
        31
      ]
    ],
    "date-time": "2006-05-31T07:17:38Z",
    "timestamp": 1149059858000
  },
  "page": "1547-1551",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 131,
  "title": "Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.",
  "prefix": "10.1073",
  "volume": "73",
  "author": [
    {
      "given": "C",
      "family": "Gorenstein",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "J R",
      "family": "Warner",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1976,
        5
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.73.5.1547",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T14:56:56Z",
    "timestamp": 1649861816000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.73.5.1547"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1976,
        5
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1976,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.73.5.1547"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.73.5.1547",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1976,
        5
      ]
    ]
  },
  "assertion": [
    {
      "value": "1976-05-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}