DOI: 10.1073/pnas.73.12.4379. Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

10.1073/pnas.73.12.4379

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The amino-terminal sequences of two polypeptides with nonsuppressible insulin-like and cell-growth-promoting activities (NSILA I and II), isolated from human serum, were determined. Of the first 31 residues, 22 are identical in NSILA I and II. Moreover, a striking structural similarity was found between NSILA and insulin B chain: 47 and 57% of residues 1-30 in NSILA I are identical to those in insulin B chain from man and tuna fish, respectively. This high degree of sequence identity is presented as evidence for homology and thus for a common evolutionary origin of insulin and NSILA. Based on these results and on these results and on biological properties of NSILA described earlier, a new designation for NSILA is proposed: insulin-like growth factor (IGF).

Bibliography

Rinderknecht, E., & Humbel, R. E. (1976). Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain. Proceedings of the National Academy of Sciences, 73(12), 4379â4381.

Authors 2

E Rinderknecht (first)
R E Humbel (additional)

References 0 Referenced 107

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:13 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:59 a.m.)
Indexed	2 months ago (June 25, 2025, 8:26 a.m.)
Issued	48 years, 8 months ago (Dec. 1, 1976)
Published	48 years, 8 months ago (Dec. 1, 1976)
Published Online	48 years, 8 months ago (Dec. 1, 1976)
Published Print	48 years, 8 months ago (Dec. 1, 1976)

Funders 0

None

BibTeX

@article{Rinderknecht_1976, title={Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.}, volume={73}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.73.12.4379}, DOI={10.1073/pnas.73.12.4379}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Rinderknecht, E and Humbel, R E}, year={1976}, month=dec, pages={4379–4381} }

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