Abstract
High sensitivity differential scanning calorimetry is applied to the study of the thermotropic behavior of mixtures of synthetic phospholipids in multilamellar aqueous suspensions. The systems dimyristoylphosphatidylcholine dipalmitoylphosphatidylcholine, and dimyristoylphosphatidylethanolamine-distearoylphosphatidylcholine, although definitely nonideal, exhibit essentially complete miscibility in both gel and liquid crystalline states, while the system dilauroylphosphatidylcholine-distearoylphosphatidylcholine is monotectic with lateral phase separation in the gel state. Comparison of the observed transition curves with theoretical curves calculated from the calorimetrically determined phase diagrams supports a literal interpretation of the phase diagrams.
Dates
Type | When |
---|---|
Created | 19 years, 2 months ago (May 31, 2006, 3:13 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 11:03 a.m.) |
Indexed | 1 hour, 18 minutes ago (Aug. 30, 2025, 12:47 p.m.) |
Issued | 48 years, 9 months ago (Nov. 1, 1976) |
Published | 48 years, 9 months ago (Nov. 1, 1976) |
Published Online | 48 years, 9 months ago (Nov. 1, 1976) |
Published Print | 48 years, 9 months ago (Nov. 1, 1976) |
@article{Mabrey_1976, title={Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.}, volume={73}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.73.11.3862}, DOI={10.1073/pnas.73.11.3862}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mabrey, S and Sturtevant, J M}, year={1976}, month=nov, pages={3862–3866} }