DOI: 10.1073/pnas.73.10.3599. A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane.

A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane.

10.1073/pnas.73.10.3599

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Valinomycin is a depsipeptide antibiotic which selectively translocates potassium across biologic membranes. This potassium ionophore was observed to inhibit phytohemagglutinin-stimulated blastogenesis and proliferation in human lymphocytes. The effect was not due to toxicity to the cells, nor appeared to be due to the effects of valinomycin as an uncoupler of oxidative phosphorylation. Furthermore, the inhibitory effect on phytohemagglutinin stimulated lymphocytes was prevented by increasing the potassium concentration of the external media. These results suggest that the interaction of mitogens with specific receptors at the cell membrane may involve mechanisms affecting cation fluxes and membrane potential. These ionic events may play a role in the transduction of membrane signals for lymphocyte stimulation.

Bibliography

Daniele, R. P., & Holian, S. K. (1976). A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane. Proceedings of the National Academy of Sciences, 73(10), 3599â3602.

Authors 2

R P Daniele (first)
S K Holian (additional)

References 0 Referenced 36

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:12 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:13 a.m.)
Indexed	9 months ago (Nov. 19, 2024, 10:59 a.m.)
Issued	48 years, 10 months ago (Oct. 1, 1976)
Published	48 years, 10 months ago (Oct. 1, 1976)
Published Online	48 years, 10 months ago (Oct. 1, 1976)
Published Print	48 years, 10 months ago (Oct. 1, 1976)

Funders 0

None

BibTeX

@article{Daniele_1976, title={A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane.}, volume={73}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.73.10.3599}, DOI={10.1073/pnas.73.10.3599}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Daniele, R P and Holian, S K}, year={1976}, month=oct, pages={3599–3602} }

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