DOI: 10.1073/pnas.72.9.3355. Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides.

Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides.

10.1073/pnas.72.9.3355

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The 9,11-azo-prostanoid III [(5Z, 9alpha, 11alpha, 13E, 15S)-9, 11-azo-15-hydroxyprosta-5,13-dienoic acid] has been obtained by synthesis and tested for biological activity in systems which are responsive to the prostaglandin endoperoxides PGH2 (I) and PGG2 (II). The azo analog III is a powerful mimic of these endoperoxides with reference to platelet aggregation and release of serotonin when added to human platelet-rich plasma. The analog III is substantially more active (about 7 fold) than PGG2 in stimulating muscle contraction in the isolated rabbit aorta strip. The very great stability of III relative to PGH2 and PGG2 and its potency as a mimic of these important substances suggest that this azo analog will be of considerable value in future studies of the prostaglandin endoperoxides.

Bibliography

Corey, E. J., Nicolaou, K. C., Machida, Y., Malmsten, C. L., & Samuelsson, B. (1975). Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proceedings of the National Academy of Sciences, 72(9), 3355â3358.

Authors 5

E J Corey (first)
K C Nicolaou (additional)
Y Machida (additional)
C L Malmsten (additional)
B Samuelsson (additional)

References 0 Referenced 83

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:10 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:07 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 3:56 p.m.)
Issued	49 years, 11 months ago (Sept. 1, 1975)
Published	49 years, 11 months ago (Sept. 1, 1975)
Published Online	49 years, 11 months ago (Sept. 1, 1975)
Published Print	49 years, 11 months ago (Sept. 1, 1975)

Funders 0

None

BibTeX

@article{Corey_1975, title={Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.9.3355}, DOI={10.1073/pnas.72.9.3355}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Corey, E J and Nicolaou, K C and Machida, Y and Malmsten, C L and Samuelsson, B}, year={1975}, month=sep, pages={3355–3358} }

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