DOI: 10.1073/pnas.72.8.2920. Interaction of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system with adenylate cyclase of Escherichia coli.

Interaction of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system with adenylate cyclase of Escherichia coli.

10.1073/pnas.72.8.2920

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Transient repression by glucose of induced enzyme synthesis involves lowering of intracellular cAMP levels. This glucose effect is partially explained by a glucose inhibition of adenylate cyclase [EC 4.6.1.1; ATP pyrophosphate-lyase(cyclizing)]. Since the phosphoenolpyruvate:sugar phosphotransferase system has been implicated in repression phenomena, an investigation was made of adenylate cyclase activity in mutants of that transport system. The results suggest that glucose phosphorylation is not necessary for inhibition of adenylate cyclase since an HPr mutant retained sensitivity to glucose inhibition. The results also suggest that adenylate cyclase activity requires the presence of Enzyme I in a phosphorylated form and that adenylate cyclase activity may be regulated by a phosphorylation-dephosphorylation mechanism.

Bibliography

Peterkofsky, A., & Gazdar, C. (1975). Interaction of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system with adenylate cyclase of Escherichia coli. Proceedings of the National Academy of Sciences, 72(8), 2920â2924.

Authors 2

A Peterkofsky (first)
C Gazdar (additional)

References 0 Referenced 60

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:01 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 6:15 p.m.)
Issued	50 years, 1 month ago (Aug. 1, 1975)
Published	50 years, 1 month ago (Aug. 1, 1975)
Published Online	50 years, 1 month ago (Aug. 1, 1975)
Published Print	50 years, 1 month ago (Aug. 1, 1975)

Funders 0

None

BibTeX

@article{Peterkofsky_1975, title={Interaction of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system with adenylate cyclase of Escherichia coli.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.8.2920}, DOI={10.1073/pnas.72.8.2920}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Peterkofsky, A and Gazdar, C}, year={1975}, month=aug, pages={2920–2924} }

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