DOI: 10.1073/pnas.72.7.2621. Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.

Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.

10.1073/pnas.72.7.2621

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in addition to the normal sensitive enzyme. The resistant dihydropteroate synthases examined are determined by an R plasmid and are smaller and less heat stable than the normal sulfonamide-sensitive enzyme. One synthase resistant to any sulfonamide tested, and to sulfanilic and arsanilic acids, was still inhibited by several non-sulfonamide analogs of p-aminobenzoate. Citrobacter and Klebsiella pneumoniae strains also show similar mechanisms of sulfonamide resistance.

Bibliography

Wise, E. M., & Abou-Donia, M. M. (1975). Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases. Proceedings of the National Academy of Sciences, 72(7), 2621â2625.

Authors 2

E M Wise (first)
M M Abou-Donia (additional)

References 0 Referenced 76

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:04 a.m.)
Indexed	39 minutes ago (Sept. 6, 2025, 1:40 p.m.)
Issued	50 years, 2 months ago (July 1, 1975)
Published	50 years, 2 months ago (July 1, 1975)
Published Online	50 years, 2 months ago (July 1, 1975)
Published Print	50 years, 2 months ago (July 1, 1975)

Funders 0

None

BibTeX

@article{Wise_1975, title={Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.7.2621}, DOI={10.1073/pnas.72.7.2621}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Wise, E M and Abou-Donia, M M}, year={1975}, month=jul, pages={2621–2625} }

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