DOI: 10.1073/pnas.72.6.2140. Voltage-dependence of drug-induced conductance in frog neuromuscular junction.

Voltage-dependence of drug-induced conductance in frog neuromuscular junction.

10.1073/pnas.72.6.2140

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Membrane currents from voltage-clamped frog muscle fibers were recorded during iontophoretic application of steady doses of carbachol, acetylcholine, and suberyldicholine to the endplate region. In the presence of these drugs, an exponentially relaxing current was observed after step changes of membrane potential. The time constant of relaxation was found to be voltage-dependent. It was equal to the time constant obtained from the autocorrelation function of drug-induced conductance fluctuations measured under similar conditions. Analysis of instantaneous current at the on- and offsets of voltageclamp pulses showed that there is no shift in equilibrium potential during the pulses.

Bibliography

Neher, E., & Sakmann, B. (1975). Voltage-dependence of drug-induced conductance in frog neuromuscular junction. Proceedings of the National Academy of Sciences, 72(6), 2140â2144.

Authors 2

E Neher (first)
B Sakmann (additional)

References 0 Referenced 70

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:08 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 15, 2024, 2:31 p.m.)
Issued	50 years, 2 months ago (June 1, 1975)
Published	50 years, 2 months ago (June 1, 1975)
Published Online	50 years, 2 months ago (June 1, 1975)
Published Print	50 years, 2 months ago (June 1, 1975)

Funders 0

None

BibTeX

@article{Neher_1975, title={Voltage-dependence of drug-induced conductance in frog neuromuscular junction.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.6.2140}, DOI={10.1073/pnas.72.6.2140}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Neher, E and Sakmann, B}, year={1975}, month=jun, pages={2140–2144} }

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