DOI: 10.1073/pnas.72.4.1469. Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity.

Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity.

10.1073/pnas.72.4.1469

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have studied androgen binding characteristics of cells for androgen insensitivity from an obligate heterozygote, who is the mother of three male pseudohermaphrodites with dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) receptor deficiency. Specific dihydrotestosterone binding by skin fibroblasts from her wrist and pubis is within the normal range and indicates that androgen insensitivity is X-linked in man and is therefore homologous to the tfm locus in the mouse. A significant population of clones from the heterozygote has deficient receptor activity, and this finding is compatible with inactivation of one X-linked allele at this locus. Our results indicate the presence of a gene on the human X chromosome that is essential for normal male sexual differentiation and provide further evidence for homology between X chromosomes of all mammals.

Bibliography

Meyer, W. J., Migeon, B. R., & Migeon, C. J. (1975). Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity. Proceedings of the National Academy of Sciences, 72(4), 1469â1472.

Authors 3

W J Meyer (first)
B R Migeon (additional)
C J Migeon (additional)

References 0 Referenced 105

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:05 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:03 a.m.)
Indexed	4 months, 2 weeks ago (April 23, 2025, 8:27 a.m.)
Issued	50 years, 5 months ago (April 1, 1975)
Published	50 years, 5 months ago (April 1, 1975)
Published Online	50 years, 5 months ago (April 1, 1975)
Published Print	50 years, 5 months ago (April 1, 1975)

Funders 0

None

BibTeX

@article{Meyer_1975, title={Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.4.1469}, DOI={10.1073/pnas.72.4.1469}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Meyer, W J and Migeon, B R and Migeon, C J}, year={1975}, month=apr, pages={1469–1472} }

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