DOI: 10.1073/pnas.72.12.5016. Homology in amino-terminal sequence of precursors to pancreatic secretory proteins.

Homology in amino-terminal sequence of precursors to pancreatic secretory proteins.

10.1073/pnas.72.12.5016

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Sequence determination of up to 24 amino-terminal residues of several putative precursors for dog pancreas secretory proteins, synthesized in vitro by translation of their mRNA's in the presence of radioactively labeled amino acids, revealed extensive sequence homology in the 16 amino-terminal residues. It is suggested that this common sequence constitutes a metabolically short-lived peptide extension which precedes the amino-terminal sequences of all pancreatic secretory proteins and that it functions in the transfer of these proteins across the microsomal membrane. This sequence was found to contain an unusually large percentage of hydrophobic residues.

Bibliography

Devillers-Thiery, A., Kindt, T., Scheele, G., & Blobel, G. (1975). Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proceedings of the National Academy of Sciences, 72(12), 5016â5020.

Authors 4

A Devillers-Thiery (first)
T Kindt (additional)
G Scheele (additional)
G Blobel (additional)

References 0 Referenced 180

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:02 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:49 a.m.)
Indexed	4 months, 1 week ago (April 11, 2025, 8:27 a.m.)
Issued	49 years, 8 months ago (Dec. 1, 1975)
Published	49 years, 8 months ago (Dec. 1, 1975)
Published Online	49 years, 8 months ago (Dec. 1, 1975)
Published Print	49 years, 8 months ago (Dec. 1, 1975)

Funders 0

None

BibTeX

@article{Devillers_Thiery_1975, title={Homology in amino-terminal sequence of precursors to pancreatic secretory proteins.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.12.5016}, DOI={10.1073/pnas.72.12.5016}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Devillers-Thiery, A and Kindt, T and Scheele, G and Blobel, G}, year={1975}, month=dec, pages={5016–5020} }

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