DOI: 10.1073/pnas.72.11.4252. Nucleotide sequence of microvariant RNA: another small replicating molecule.

Nucleotide sequence of microvariant RNA: another small replicating molecule.

10.1073/pnas.72.11.4252

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Microvariant RNA, a small self-replicating molecule (114 nucleotides long), has been isolated from Qbeta replicase reactions incubated in the absence of exogenous template. Its complete nucleotide sequence has been determined. Comparison with MDV-1 RNA, a somewhat larger endogenous Qbeta replicase product (220 nucleotides long) that had previously been characterized, revealed no significant sequence similarity. Since Qbeta replicase can mediate the synthesis of both of these disparate RNA molecules, primary sequence cannot be the sole determining factor in the processes of enzyme recognition and replication. This implies that the key is to be found in the secondary or tertiary structures. The availability of two different replicating molecules of defined sequence should aid in identifying these critical structural features.

Bibliography

Mills, D. R., Kramer, F. R., Dobkin, C., Nishihara, T., & Speigelman, S. (1975). Nucleotide sequence of microvariant RNA: another small replicating molecule. Proceedings of the National Academy of Sciences, 72(11), 4252â4256.

Authors 5

D R Mills (first)
F R Kramer (additional)
C Dobkin (additional)
T Nishihara (additional)
S Speigelman (additional)

References 0 Referenced 27

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 3:02 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:36 a.m.)
Indexed	1 year, 9 months ago (Nov. 7, 2023, 1:46 a.m.)
Issued	49 years, 10 months ago (Nov. 1, 1975)
Published	49 years, 10 months ago (Nov. 1, 1975)
Published Online	49 years, 10 months ago (Nov. 1, 1975)
Published Print	49 years, 10 months ago (Nov. 1, 1975)

Funders 0

None

BibTeX

@article{Mills_1975, title={Nucleotide sequence of microvariant RNA: another small replicating molecule.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.11.4252}, DOI={10.1073/pnas.72.11.4252}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mills, D R and Kramer, F R and Dobkin, C and Nishihara, T and Speigelman, S}, year={1975}, month=nov, pages={4252–4256} }

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