Abstract
A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cells; (2) its antiviral activity was species specific; (3) its activity was completely neutralized by mouse anti-interferon serum. The synthesis of interferon in this cell-free system requires the presence of spermine.
Dates
Type | When |
---|---|
Created | 19 years, 3 months ago (May 31, 2006, 3:02 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 10:23 a.m.) |
Indexed | 1 year, 9 months ago (Nov. 23, 2023, 2:59 p.m.) |
Issued | 49 years, 11 months ago (Oct. 1, 1975) |
Published | 49 years, 11 months ago (Oct. 1, 1975) |
Published Online | 49 years, 11 months ago (Oct. 1, 1975) |
Published Print | 49 years, 11 months ago (Oct. 1, 1975) |
@article{Thang_1975, title={Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.}, volume={72}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.72.10.3975}, DOI={10.1073/pnas.72.10.3975}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Thang, M N and Thang, D C and De Maeyer, E and Montagnier, L}, year={1975}, month=oct, pages={3975–3977} }