DOI: 10.1073/pnas.71.10.3913. The Molecular Weight of the Major Glycoprotein from the Human Erythrocyte Membrane

The Molecular Weight of the Major Glycoprotein from the Human Erythrocyte Membrane

10.1073/pnas.71.10.3913

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacrylamide gels that cannot be interpreted in terms of molecular weight. Anomalous sodium dodecyl sulfate binding may be a general characteristic of many intrinsic membrane proteins even if they are not glycoproteins, and such proteins are likely to have mobilities in sodium dodecyl sulfate-gel electrophoresis that do not correspond to the mobilities of water soluble proteins of identical molecular weight.

Bibliography

Grefrath, S. P., & Reynolds, J. A. (1974). The Molecular Weight of the Major Glycoprotein from the Human Erythrocyte Membrane. Proceedings of the National Academy of Sciences, 71(10), 3913â3916.

Authors 2

Stuart P. Grefrath (first)
Jacqueline A. Reynolds (additional)

References 0 Referenced 99

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:48 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:40 a.m.)
Indexed	2 months ago (July 2, 2025, 5:18 a.m.)
Issued	50 years, 11 months ago (Oct. 1, 1974)
Published	50 years, 11 months ago (Oct. 1, 1974)
Published Online	50 years, 11 months ago (Oct. 1, 1974)
Published Print	50 years, 11 months ago (Oct. 1, 1974)

Funders 0

None

BibTeX

@article{Grefrath_1974, title={The Molecular Weight of the Major Glycoprotein from the Human Erythrocyte Membrane}, volume={71}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.71.10.3913}, DOI={10.1073/pnas.71.10.3913}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Grefrath, Stuart P. and Reynolds, Jacqueline A.}, year={1974}, month=oct, pages={3913–3916} }

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