DOI: 10.1073/pnas.70.5.1564. Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes

Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes

10.1073/pnas.70.5.1564

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel - , strains of Escherichia coli are starved for required amino acids. These compounds are synthesized on ribosomes, in the presence of the product of the rel gene, from GDP and GTP; ATP is used as the phosphate donor. The signal for making these compounds is the presence of an uncharged tRNA in the ribosomal acceptor site. These compounds are not accumulated if the ribosomes are actively engaged in protein synthesis.

Bibliography

Haseltine, W. A., & Block, R. (1973). Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes. Proceedings of the National Academy of Sciences, 70(5), 1564â1568.

Authors 2

William A. Haseltine (first)
Ricardo Block (additional)

References 0 Referenced 399

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:45 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:21 a.m.)
Indexed	6 days, 14 hours ago (Aug. 29, 2025, 5:55 a.m.)
Issued	52 years, 4 months ago (May 1, 1973)
Published	52 years, 4 months ago (May 1, 1973)
Published Online	52 years, 4 months ago (May 1, 1973)
Published Print	52 years, 4 months ago (May 1, 1973)

Funders 0

None

BibTeX

@article{Haseltine_1973, title={Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes}, volume={70}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.70.5.1564}, DOI={10.1073/pnas.70.5.1564}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Haseltine, William A. and Block, Ricardo}, year={1973}, month=may, pages={1564–1568} }

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