DOI: 10.1073/pnas.70.4.1214. Immobilized Catecholamine and Cocaine Effects on Contractility of Cardiac Muscle

Immobilized Catecholamine and Cocaine Effects on Contractility of Cardiac Muscle

10.1073/pnas.70.4.1214

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Isoproterenol, norepinephrine, and epinephrine covalently bound to glass beads exert a positive inotropic effect on isometrically contracting papillary muscles from cats. Immobilized isoproterenol maintains increases in force and velocity of contraction for more than 5 hr. 1 μM Cocaine potentiates the action of immobilized norepinephrine, isoproterenol, and epinephrine, but not of isoproterenol in solution. The data presented indicate that the effects of immobilized catecholamines are not due to their coming off the glass. The effects observed with cocaine and immobilized catecholamines are not altered by prior treatment of the muscle with reserpine. These results suggest that the major site of catecholamine action is on receptors located on the extended surface of myocardial cells and a post-junctional site for cocaine potentiation.

Authors 5

J. Craig Venter (first)
John Ross (additional)
Jack E. Dixon (additional)
Steven E. Mayer (additional)
Nathan O. Kaplan (additional)

References 0 Referenced 23

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:42 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:45 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 3:59 p.m.)
Issued	52 years, 5 months ago (April 1, 1973)
Published	52 years, 5 months ago (April 1, 1973)
Published Online	52 years, 5 months ago (April 1, 1973)
Published Print	52 years, 5 months ago (April 1, 1973)

Funders 0

None

BibTeX

@article{Venter_1973, title={Immobilized Catecholamine and Cocaine Effects on Contractility of Cardiac Muscle}, volume={70}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.70.4.1214}, DOI={10.1073/pnas.70.4.1214}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Venter, J. Craig and Ross, John and Dixon, Jack E. and Mayer, Steven E. and Kaplan, Nathan O.}, year={1973}, month=apr, pages={1214–1217} }

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