DOI: 10.1073/pnas.70.2.456. Illicit Transport: The Oligopeptide Permease

Illicit Transport: The Oligopeptide Permease

10.1073/pnas.70.2.456

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The oligopeptide permease of Escherichia coli has been characterized by Payne, Gilvarg, and their colleagues. We have confirmed its existence in Salmonella typhimurium , and have isolated a series of mutants lacking the permease. We use this transport system for smuggling a histidine biosynthetic intermediate, histidinol phosphate ester, into the bacteria as its glycylglycyl derivative, Gly-Gly-histidinol phosphate. Free histidinol phosphate ester is not transported into Salmonella . Several amino-acid analogues are shown to be much more inhibitory to Salmonella when presented to the bacteria in the form of tripeptides than as the free amino acids. The implications of this work for practical purposes are discussed. The synthesis of Gly-Gly-histidinol phosphate is described.

Bibliography

Ames, B. N., Ames, G. F.-L., Young, J. D., Tsuchiya, D., & Lecocq, J. (1973). Illicit Transport: The Oligopeptide Permease. Proceedings of the National Academy of Sciences, 70(2), 456â458.

Authors 5

Bruce N. Ames (first)
Giovanna Ferro-Luzzi Ames (additional)
Janis Dillaha Young (additional)
Dorinne Tsuchiya (additional)
Jean Lecocq (additional)

References 0 Referenced 75

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:42 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:38 a.m.)
Indexed	2 months, 1 week ago (June 23, 2025, 12:42 p.m.)
Issued	52 years, 7 months ago (Feb. 1, 1973)
Published	52 years, 7 months ago (Feb. 1, 1973)
Published Online	52 years, 7 months ago (Feb. 1, 1973)
Published Print	52 years, 7 months ago (Feb. 1, 1973)

Funders 0

None

BibTeX

@article{Ames_1973, title={Illicit Transport: The Oligopeptide Permease}, volume={70}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.70.2.456}, DOI={10.1073/pnas.70.2.456}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ames, Bruce N. and Ames, Giovanna Ferro-Luzzi and Young, Janis Dillaha and Tsuchiya, Dorinne and Lecocq, Jean}, year={1973}, month=feb, pages={456–458} }

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