DOI: 10.1073/pnas.69.6.1384. Hyaluronate in Morphogenesis: Inhibition of Chondrogenesis <i>In Vitro</i>

Hyaluronate in Morphogenesis: Inhibition of Chondrogenesis In Vitro

10.1073/pnas.69.6.1384

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Purified hyaluronate, at a concentration as low as 1 ng/ml, blocks the formation of colonies and cartilage nodules in stationary cultures of cells, isolated by treatment with trypsin, from embryonic chick somites and limb buds. This phenomenon in vitro is correlated with sequences of hyaluronate production and hyaluronidase activity during chondrogenesis in embryonic and regenerating tissues in vivo . An hypothesis is proposed in which hyaluronate acts as a regulator or inhibitor of mesenchymal cell aggregation in embryogenesis, its synthesis and removal being part of the mechanism of timing of migration, aggregation, and subsequent differentiation.

Bibliography

Toole, B. P., Jackson, G., & Gross, J. (1972). Hyaluronate in Morphogenesis: Inhibition of Chondrogenesis In Vitro. Proceedings of the National Academy of Sciences, 69(6), 1384â1386.

Authors 3

Bryan P. Toole (first)
Geraldine Jackson (additional)
Jerome Gross (additional)

References 0 Referenced 146

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:36 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:46 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 6, 2024, 2:56 p.m.)
Issued	53 years, 3 months ago (June 1, 1972)
Published	53 years, 3 months ago (June 1, 1972)
Published Online	53 years, 3 months ago (June 1, 1972)
Published Print	53 years, 3 months ago (June 1, 1972)

Funders 0

None

BibTeX

@article{Toole_1972, title={Hyaluronate in Morphogenesis: Inhibition of Chondrogenesis In Vitro}, volume={69}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.69.6.1384}, DOI={10.1073/pnas.69.6.1384}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Toole, Bryan P. and Jackson, Geraldine and Gross, Jerome}, year={1972}, month=jun, pages={1384–1386} }

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