DOI: 10.1073/pnas.69.5.1156. Role of DNA Polymerase I and the <i>rec</i> System in Excision-Repair in <i>Escherichia coli</i>

Role of DNA Polymerase I and the rec System in Excision-Repair in Escherichia coli

10.1073/pnas.69.5.1156

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The DNA polymerase I-deficient mutant polA 1 is shown to perform an increased amount of UV-stimulated repair synthesis relative to its pol + parent. In contrast, a recA recB double mutant is found to perform little detectable repair synthesis. Analysis of the density distribution of sheared DNA of the recA recB mutant reveals that none of the repair synthesis in this strain is in the large repair patches previously demonstrated by us in wild-type strains. These results are interpreted in terms of a model involving both DNA polymerase I and the rec system in the excision-repair process, with polymerase I performing an efficient short patch repair and rec system enzymes producing predominantly large patches of repair synthesis.

Bibliography

Cooper, P. K., & Hanawalt, P. C. (1972). Role of DNA Polymerase I and the rec System in Excision-Repair in Escherichia coli. Proceedings of the National Academy of Sciences, 69(5), 1156â1160.

Authors 2

Priscilla K. Cooper (first)
Philip C. Hanawalt (additional)

References 0 Referenced 121

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:33 a.m.)
Indexed	1 year, 1 month ago (July 26, 2024, 5:51 p.m.)
Issued	53 years, 4 months ago (May 1, 1972)
Published	53 years, 4 months ago (May 1, 1972)
Published Online	53 years, 4 months ago (May 1, 1972)
Published Print	53 years, 4 months ago (May 1, 1972)

Funders 0

None

BibTeX

@article{Cooper_1972, title={Role of DNA Polymerase I and the rec System in Excision-Repair in Escherichia coli}, volume={69}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.69.5.1156}, DOI={10.1073/pnas.69.5.1156}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Cooper, Priscilla K. and Hanawalt, Philip C.}, year={1972}, month=may, pages={1156–1160} }

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