DOI: 10.1073/pnas.69.10.2995. Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

10.1073/pnas.69.10.2995

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3′:5′-cyclic AMP: prostaglandin E 1 , cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.

Bibliography

Strom, T. B., Deisseroth, A., Morganroth, J., Carpenter, C. B., & Merrill, J. P. (1972). Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase. Proceedings of the National Academy of Sciences, 69(10), 2995â2999.

Authors 5

Terry B. Strom (first)
Albert Deisseroth (additional)
Joel Morganroth (additional)
Charles B. Carpenter (additional)
John P. Merrill (additional)

References 0 Referenced 89

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:32 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:43 a.m.)
Indexed	5 months ago (March 22, 2025, 4:55 a.m.)
Issued	52 years, 10 months ago (Oct. 1, 1972)
Published	52 years, 10 months ago (Oct. 1, 1972)
Published Online	52 years, 10 months ago (Oct. 1, 1972)
Published Print	52 years, 10 months ago (Oct. 1, 1972)

Funders 0

None

BibTeX

@article{Strom_1972, title={Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase}, volume={69}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.69.10.2995}, DOI={10.1073/pnas.69.10.2995}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Strom, Terry B. and Deisseroth, Albert and Morganroth, Joel and Carpenter, Charles B. and Merrill, John P.}, year={1972}, month=oct, pages={2995–2999} }

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