DOI: 10.1073/pnas.68.9.2185. Control of λ Repressor Synthesis

10.1073/pnas.68.9.2185

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Direct measurements of the intracellular level of λ repressor have been made by a DNA-filter assay and a radioimmune assay. Transcription of cI , the structural gene for repressor, appears to initiate at two different promoters, prm and pre . Promoter pre is activated during the establishment of lysogeny by the action of cII and cIII proteins at the DNA site cY . Phage mutated in cII, cIII , or cY do not make a normal burst of repressor after infection and do not efficiently lysogenize the cell. Cro product stops repressor synthesis midway in the infective cycle. Promoter prm maintains the repressor level in established lysogens. Delection mapping places it very near the right operator ( Or ). Prm is activated by repressor bound to the right operator. In the absence of cII or cIII protein, repressor synthesis requires active repressor and only proceeds on genomes able to bind repressor at Or .

Bibliography

Reichardt, L., & Kaiser, A. D. (1971). Control of Î» Repressor Synthesis. Proceedings of the National Academy of Sciences, 68(9), 2185â2189.

Authors 2

Louis Reichardt (first)
A. D. Kaiser (additional)

References 0 Referenced 150

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:30 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:32 a.m.)
Indexed	4 months, 2 weeks ago (April 11, 2025, 4:48 a.m.)
Issued	53 years, 11 months ago (Sept. 1, 1971)
Published	53 years, 11 months ago (Sept. 1, 1971)
Published Online	53 years, 11 months ago (Sept. 1, 1971)
Published Print	53 years, 11 months ago (Sept. 1, 1971)

Funders 0

None

BibTeX

@article{Reichardt_1971, title={Control of λ Repressor Synthesis}, volume={68}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.68.9.2185}, DOI={10.1073/pnas.68.9.2185}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Reichardt, Louis and Kaiser, A. D.}, year={1971}, month=sep, pages={2185–2189} }

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