DOI: 10.1073/pnas.68.5.920. Antibody to the RNA-Dependent DNA Polymerase of Mammalian C-Type RNA Tumor Viruses

Antibody to the RNA-Dependent DNA Polymerase of Mammalian C-Type RNA Tumor Viruses

10.1073/pnas.68.5.920

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA-containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related.

Bibliography

Aaronson, S. A., Parks, W. P., Scolnick, E. M., & Todaro, G. J. (1971). Antibody to the RNA-Dependent DNA Polymerase of Mammalian C-Type RNA Tumor Viruses. Proceedings of the National Academy of Sciences, 68(5), 920â924.

Authors 4

Stuart A. Aaronson (first)
Wade P. Parks (additional)
Edward M. Scolnick (additional)
George J. Todaro (additional)

References 0 Referenced 61

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:28 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:35 a.m.)
Indexed	1 year, 7 months ago (Jan. 14, 2024, 11:21 a.m.)
Issued	54 years, 3 months ago (May 1, 1971)
Published	54 years, 3 months ago (May 1, 1971)
Published Online	54 years, 3 months ago (May 1, 1971)
Published Print	54 years, 3 months ago (May 1, 1971)

Funders 0

None

BibTeX

@article{Aaronson_1971, title={Antibody to the RNA-Dependent DNA Polymerase of Mammalian C-Type RNA Tumor Viruses}, volume={68}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.68.5.920}, DOI={10.1073/pnas.68.5.920}, number={5}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Aaronson, Stuart A. and Parks, Wade P. and Scolnick, Edward M. and Todaro, George J.}, year={1971}, month=may, pages={920–924} }

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