DOI: 10.1073/pnas.68.4.773. The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates

The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates

10.1073/pnas.68.4.773

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The 2-aminopurine-induced transition, A·T → G·C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A·T base pair by a G·C base pair.

Bibliography

Koch, R. E. (1971). The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates. Proceedings of the National Academy of Sciences, 68(4), 773â776.

Authors 1

Robert E. Koch (first)

References 0 Referenced 40

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:28 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:23 a.m.)
Indexed	1 year, 5 months ago (March 21, 2024, 9:07 a.m.)
Issued	54 years, 4 months ago (April 1, 1971)
Published	54 years, 4 months ago (April 1, 1971)
Published Online	54 years, 4 months ago (April 1, 1971)
Published Print	54 years, 4 months ago (April 1, 1971)

Funders 0

None

BibTeX

@article{Koch_1971, title={The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates}, volume={68}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.68.4.773}, DOI={10.1073/pnas.68.4.773}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Koch, Robert E.}, year={1971}, month=apr, pages={773–776} }

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