DOI: 10.1073/pnas.68.10.2564. Lateral Diffusion of Phospholipids in a Vesicle Membrane

Lateral Diffusion of Phospholipids in a Vesicle Membrane

10.1073/pnas.68.10.2564

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Nuclear-resonance spectra of phosphatidylcholine (PC) vesicles are broadened by spin-labeled PC. The broadening of the N -methyl proton line is proportional to spin-labeled PC concentration; the broadening by 1 molecule in 100 of spin-labeled PC is 9.7 Hz at 35°C; the broadening is not due to collisions between vesicles, exchange of spin label between vesicles, or fusion of vesicles. These findings are proof of rapid diffusion in the plane of the PC bilayer (lateral diffusion). A further study of the broadening reveals the molecular frequency of the translation step for lateral diffusion to be much greater than 3 × 10 3 sec -1 at 0°C.

Bibliography

Kornberg, R. D., & McConnell, H. M. (1971). Lateral Diffusion of Phospholipids in a Vesicle Membrane. Proceedings of the National Academy of Sciences, 68(10), 2564â2568.

Authors 2

Roger D. Kornberg (first)
Harden M. McConnell (additional)

References 0 Referenced 166

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:25 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:47 a.m.)
Indexed	32 minutes ago (Sept. 2, 2025, 11:53 p.m.)
Issued	53 years, 11 months ago (Oct. 1, 1971)
Published	53 years, 11 months ago (Oct. 1, 1971)
Published Online	53 years, 11 months ago (Oct. 1, 1971)
Published Print	53 years, 11 months ago (Oct. 1, 1971)

Funders 0

None

BibTeX

@article{Kornberg_1971, title={Lateral Diffusion of Phospholipids in a Vesicle Membrane}, volume={68}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.68.10.2564}, DOI={10.1073/pnas.68.10.2564}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kornberg, Roger D. and McConnell, Harden M.}, year={1971}, month=oct, pages={2564–2568} }

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