DOI: 10.1073/pnas.68.1.72. Unexpectedly Large Size of Globin Messenger Ribonucleic Acid

Unexpectedly Large Size of Globin Messenger Ribonucleic Acid

10.1073/pnas.68.1.72

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The globin messenger RNA of rabbit reticulocytes is identified on the basis of its presence in polysomes, absence from single ribosomes, and sedimentation coefficient of 9 S. Analysis of this RNA by electrophoresis in polyacrylamide gels provides evidence that its size is unexpectedly large (approximately 650 nucleotides) for a messenger coding for the 141 and 146 amino acids of a globin polypeptide. Reticulocyte RNA molecules were labeled in vivo with [ 32 P]orthophosphate. Globin messenger RNA and transfer RNA appear to be synthesized late in erythropoiesis, whereas ribosomal RNA and 5S RNA are synthesized at the beginning stages of cytodifferentiation. At least one fragment of ribosomal RNA accumulates in erythrocytes in the terminal stages of maturation.

Bibliography

Gaskill, P., & Kabat, D. (1971). Unexpectedly Large Size of Globin Messenger Ribonucleic Acid. Proceedings of the National Academy of Sciences, 68(1), 72â75.

Authors 2

Pauline Gaskill (first)
David Kabat (additional)

References 0 Referenced 56

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:24 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:40 a.m.)
Indexed	1 year, 2 months ago (June 7, 2024, 7:37 p.m.)
Issued	54 years, 7 months ago (Jan. 1, 1971)
Published	54 years, 7 months ago (Jan. 1, 1971)
Published Online	54 years, 7 months ago (Jan. 1, 1971)
Published Print	54 years, 7 months ago (Jan. 1, 1971)

Funders 0

None

BibTeX

@article{Gaskill_1971, title={Unexpectedly Large Size of Globin Messenger Ribonucleic Acid}, volume={68}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.68.1.72}, DOI={10.1073/pnas.68.1.72}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Gaskill, Pauline and Kabat, David}, year={1971}, month=jan, pages={72–75} }

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