Abstract
Cordycepin (3′-deoxyadenosine) suppresses the labeling of messenger RNA in HeLa cells. The drug has no effect on either the labeling of nuclear heterogeneous RNA or on the transport of messenger RNA into the cytoplasm. The results suggest that messenger RNA and nuclear heterogeneous RNA are synthesized separately, and that the transcription of messenger RNA is inhibited by the drug.
Dates
Type | When |
---|---|
Created | 19 years, 2 months ago (May 31, 2006, 2:21 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 10:19 a.m.) |
Indexed | 4 weeks, 1 day ago (July 24, 2025, 7:39 a.m.) |
Issued | 54 years, 8 months ago (Dec. 1, 1970) |
Published | 54 years, 8 months ago (Dec. 1, 1970) |
Published Online | 54 years, 8 months ago (Dec. 1, 1970) |
Published Print | 54 years, 8 months ago (Dec. 1, 1970) |
@article{Penman_1970, title={Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin}, volume={67}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.67.4.1878}, DOI={10.1073/pnas.67.4.1878}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Penman, S. and Rosbash, M. and Penman, M.}, year={1970}, month=dec, pages={1878–1885} }