DOI: 10.1073/pnas.67.4.1741. Cell Density-Dependent Changes of Glycolipid Concentrations in Fibroblasts, and Loss of This Response in Virus-Transformed Cells

Cell Density-Dependent Changes of Glycolipid Concentrations in Fibroblasts, and Loss of This Response in Virus-Transformed Cells

10.1073/pnas.67.4.1741

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The glycolipids of normal fibroblasts cells at different stages of growth and with differing degrees of susceptibility to contact inhibition have been analyzed, as well as the glycolipids of virally transformed cells. The concentrations (per mg protein) of certain glycolipids, including galactosylgalactosyl-glucosyl-, N -acetylneuraminosylgalactosylglucosyl-, and N -acetylneuraminosyl-( N -acetylneuraminosyl)galactosylglucosyl-c eramide, increase on cell-to-cell contact of susceptible cells. The concentrations of these glycolipids decrease when susceptibility to contact inhibition is lost as a result of extensive passage in vitro or transformation by simian virus 40 or polyoma virus, and in all the malignant cells examined, the concentrations of these glycolipids were independent of cell density.

Bibliography

Hakomori, S. (1970). Cell Density-Dependent Changes of Glycolipid Concentrations in Fibroblasts, and Loss of This Response in Virus-Transformed Cells. Proceedings of the National Academy of Sciences, 67(4), 1741â1747.

Authors 1

Sen-itiroh Hakomori (first)

References 0 Referenced 136

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:20 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 7, 2025, 4:55 a.m.)
Issued	54 years, 8 months ago (Dec. 1, 1970)
Published	54 years, 8 months ago (Dec. 1, 1970)
Published Online	54 years, 8 months ago (Dec. 1, 1970)
Published Print	54 years, 8 months ago (Dec. 1, 1970)

Funders 0

None

BibTeX

@article{Hakomori_1970, title={Cell Density-Dependent Changes of Glycolipid Concentrations in Fibroblasts, and Loss of This Response in Virus-Transformed Cells}, volume={67}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.67.4.1741}, DOI={10.1073/pnas.67.4.1741}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hakomori, Sen-itiroh}, year={1970}, month=dec, pages={1741–1747} }

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