DOI: 10.1073/pnas.67.2.696. The Selective Inhibition of Protein Initiation by T4 Phage-Induced Factors

The Selective Inhibition of Protein Initiation by T4 Phage-Induced Factors

10.1073/pnas.67.2.696

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia coli template RNA with uninfected ribosomes while efficiently supporting the formation of initiation complexes with T4 template RNA. T4 factors also permit T5 template RNA to bind to E. coli ribosomes, which indicates that the T4 selective effect is not exclusive for T4 templates. Other evidence indicates that T4 factors do not alter the process of polypeptide chain elongation.

Bibliography

Klem, E. B., Hsu, W.-T., & Weiss, S. B. (1970). The Selective Inhibition of Protein Initiation by T4 Phage-Induced Factors. Proceedings of the National Academy of Sciences, 67(2), 696â701.

Authors 3

Edward B. Klem (first)
Wen-Tah Hsu (additional)
Samuel B. Weiss (additional)

References 0 Referenced 25

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:23 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:44 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 5:20 p.m.)
Issued	54 years, 11 months ago (Oct. 1, 1970)
Published	54 years, 11 months ago (Oct. 1, 1970)
Published Online	54 years, 11 months ago (Oct. 1, 1970)
Published Print	54 years, 11 months ago (Oct. 1, 1970)

Funders 0

None

BibTeX

@article{Klem_1970, title={The Selective Inhibition of Protein Initiation by T4 Phage-Induced Factors}, volume={67}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.67.2.696}, DOI={10.1073/pnas.67.2.696}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Klem, Edward B. and Hsu, Wen-Tah and Weiss, Samuel B.}, year={1970}, month=oct, pages={696–701} }

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