DOI: 10.1073/pnas.67.1.99. Peptide Chain Termination with Mammalian Release Factor

Peptide Chain Termination with Mammalian Release Factor

10.1073/pnas.67.1.99

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N -formylmethionine from mammalian [ N -formylmethionyl-tRNA f ·ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.

Bibliography

Goldstein, J. L., Beaudet, A. L., & Caskey, C. T. (1970). Peptide Chain Termination with Mammalian Release Factor. Proceedings of the National Academy of Sciences, 67(1), 99â106.

Authors 3

J. L. Goldstein (first)
A. L. Beaudet (additional)
C. T. Caskey (additional)

References 0 Referenced 42

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:22 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:33 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:15 a.m.)
Issued	54 years, 11 months ago (Sept. 1, 1970)
Published	54 years, 11 months ago (Sept. 1, 1970)
Published Online	54 years, 11 months ago (Sept. 1, 1970)
Published Print	54 years, 11 months ago (Sept. 1, 1970)

Funders 0

None

BibTeX

@article{Goldstein_1970, title={Peptide Chain Termination with Mammalian Release Factor}, volume={67}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.67.1.99}, DOI={10.1073/pnas.67.1.99}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Goldstein, J. L. and Beaudet, A. L. and Caskey, C. T.}, year={1970}, month=sep, pages={99–106} }

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