DOI: 10.1073/pnas.66.4.1067. OXIDIZED RNASE AS A PROTEIN MODEL HAVING NO CONTRIBUTION TO THE HYDROGEN EXCHANGE RATE FROM CONFORMATIONAL RESTRICTIONS

OXIDIZED RNASE AS A PROTEIN MODEL HAVING NO CONTRIBUTION TO THE HYDROGEN EXCHANGE RATE FROM CONFORMATIONAL RESTRICTIONS

10.1073/pnas.66.4.1067

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

As oxidized RNase is a model for the random conformation state of RNase, the hydrogen exchange kinetics of oxidized RNase approximate the intrinsic conformation-independent chemical exchange rate of the native protein. The energy of activation, the pH min , and the k min of oxidized RNase exchange rates are similar to those reported for amino acid homopolymers. However, unlike the exchange from homopolymers, the exchange from oxidized RNase is characterized by a distribution of first-order rates. This distribution is important to the analysis of exchange from native proteins in terms of classes of sites which share common structural properties.

Bibliography

Woodward, C. K., & Rosenberg, A. (1970). OXIDIZED RNASE AS A PROTEIN MODEL HAVING NO CONTRIBUTION TO THE HYDROGEN EXCHANGE RATE FROM CONFORMATIONAL RESTRICTIONS. Proceedings of the National Academy of Sciences, 66(4), 1067â1074.

Authors 2

C. K. Woodward (first)
Andreas Rosenberg (additional)

References 0 Referenced 31

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:26 a.m.)
Indexed	4 months, 3 weeks ago (April 5, 2025, 12:23 p.m.)
Issued	55 years, 1 month ago (Aug. 1, 1970)
Published	55 years, 1 month ago (Aug. 1, 1970)
Published Online	55 years, 1 month ago (Aug. 1, 1970)
Published Print	55 years, 1 month ago (Aug. 1, 1970)

Funders 0

None

BibTeX

@article{Woodward_1970, title={OXIDIZED RNASE AS A PROTEIN MODEL HAVING NO CONTRIBUTION TO THE HYDROGEN EXCHANGE RATE FROM CONFORMATIONAL RESTRICTIONS}, volume={66}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.66.4.1067}, DOI={10.1073/pnas.66.4.1067}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Woodward, C. K. and Rosenberg, Andreas}, year={1970}, month=aug, pages={1067–1074} }

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