DOI: 10.1073/pnas.64.4.1284. GENETICS OF SOMATIC MAMMALIAN CELLS, X. COMPLEMENTATION ANALYSIS OF GLYCINE-REQUIRING MUTANTS

GENETICS OF SOMATIC MAMMALIAN CELLS, X. COMPLEMENTATION ANALYSIS OF GLYCINE-REQUIRING MUTANTS

10.1073/pnas.64.4.1284

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Complementation analysis at the single gene level has been carried out on 13 different, recessive, glycine-requiring mutants produced by action of mutagenic agents on the CHO-K1 Chinese hamster cell. The mutants form four different complementation classes indicating that at least four separate genes can produce a growth requirement for glycine. The four classes of mutants can be distinguished biochemically as well as genetically. Existence of these four mutant classes appears to explain the preponderance of the glycine-requiring forms in the auxotrophs produced by treatment of the parental cell with mutagenic agents.

Bibliography

Kao, F.-T., Chasin, L., & Puck, T. T. (1969). GENETICS OF SOMATIC MAMMALIAN CELLS, X. COMPLEMENTATION ANALYSIS OF GLYCINE-REQUIRING MUTANTS. Proceedings of the National Academy of Sciences, 64(4), 1284â1291.

Authors 3

Fa-Ten Kao (first)
Lawrence Chasin (additional)
Theodore T. Puck (additional)

References 0 Referenced 95

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:17 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:40 a.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:37 a.m.)
Issued	55 years, 9 months ago (Dec. 1, 1969)
Published	55 years, 9 months ago (Dec. 1, 1969)
Published Online	55 years, 9 months ago (Dec. 1, 1969)
Published Print	55 years, 9 months ago (Dec. 1, 1969)

Funders 0

None

BibTeX

@article{Kao_1969, title={GENETICS OF SOMATIC MAMMALIAN CELLS, X. COMPLEMENTATION ANALYSIS OF GLYCINE-REQUIRING MUTANTS}, volume={64}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.64.4.1284}, DOI={10.1073/pnas.64.4.1284}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kao, Fa-Ten and Chasin, Lawrence and Puck, Theodore T.}, year={1969}, month=dec, pages={1284–1291} }

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